Advanced Patient Assessment Practice Exam 2025 – Comprehensive Prep Resource

The left ventricle normally has the largest muscle mass among the heart chambers. This is primarily due to its critical role in systemic circulation. The left ventricle is responsible for pumping oxygenated blood to the rest of the body, which requires it to generate enough pressure to overcome the systemic vascular resistance. Consequently, it has a thicker muscular wall compared to the other chambers to facilitate this powerful contraction.

In contrast, the right ventricle pumps blood to the lungs, which only requires it to overcome the much lower pressure of the pulmonary circulation. Therefore, while the right ventricle does have significant muscularity, it is not as substantial as that of the left ventricle.

The atria, including the right and left atrium, have thinner walls since they only need to receive blood and push it into the ventricles without requiring the same force. This anatomical differentiation ensures efficient functioning of the heart according to the distinct circulatory demands each chamber faces.